A/G rs12983273 T/C(Continued)Breast Cancer: Targets and Therapy 2015:submit your manuscript | www.dovepress.comDovepressGraveel et alDovepressTable 2 (Continued)Gene locus MIR423 SNP rs6505162 A/C Comments premiRNA Population Caucasian Jewish BRCA2 carriers Asians Caucasians African Americans european Americans African Americans european Americans African Americans european Americans Chinese Asians Caucasians Asians Caucasians Chinese Caucasians Asians Caucasians Asians Caucasians Asians Caucasians African Americans european Americans African Americans european Americans African Americans european Americans African Americans european Americans Asians Caucasians African Americans european Americans African Americans european Americans African Americans european Americans African Americans european Americans African Americans european Americans African Americans european Americans African Americans european Americans Jewish BRCA2 carriers Caucasian italian Chinese Jewish BRCA1 carriers Chinese Clinical observation Reduced CPI-203 danger Later age of onset No danger CPI-203 chemical information association No threat association No risk association Decreased threat of eR+ BC No threat association enhanced overall risk No danger association enhanced threat of eR- BC increased risk increased threat No threat association elevated threat No risk association increased threat No danger association improved danger No danger association improved danger No risk association Decreased danger No threat association increased overall danger No danger association No danger association elevated all round risk No risk association Decreased threat of eR+ BC elevated danger of eR- BC No threat association Decreased danger No danger association enhanced threat of eR+ No danger association No danger association Decreased danger of eR- BC Decreased risk of eR+ BC No danger association Decreased risk of eR+ No risk association No danger association elevated general risk Decreased general threat No danger association No danger association elevated threat of eR- BC enhanced risk improved risk enhanced threat increased danger in eR+ earlier age of onset improved risk (A allele) earlier age of onset (C allele) Decreased threat Decreased risk improved danger Reduced survival Reference 150 142 38 33 33 33 36 151 152 32 147 153 31 141 33 33 33 33 141 33 33 33 33 33 33 33 142 srep39151 43 154 155 156 jir.2014.0227 157 158 159MIR455 MIR487 MIR495 MIRrs2060133 C/G rs1951032 G/A rs2281611 C/A rs3746444 A/Grs3746444 T/CMIR513A-2 MIR544 MIR548A-2 MIR595 MIR605 MIR606 MIR608 MIRrs2018562 A/G rs10144193 A/T rs878175 A/G rs4909238 A/G rs2043556 *A rs12266981 G/A rs4919510 C/G rs8041885 A/G rs8041044 C/AMIR659 MIRrs5750504 T/A rs12586258 G/A rs7141987 A/GATF1 3 UTR BMPR1B three UTR BRCA1 3 UTR HPGD 3 UTR IGF-1R 3 UTR IL23R 3 UTRrs11169571 C/T rs1434536 C/T rs799917 C/T rs8752 G/A rs28674628 A/G rs10889677 A/CmiR320 MRe miR125b MRe miR638 MRe miR4855p MRe miR5155p MRe let7 MReIQGAP1 three UTR ITGB4 three UTRrs1042538 A/T rs743554 A/GmiR124 MRe miR34a MRepredictedChinese Swedish(Continued)submit your manuscript | www.dovepress.comBreast Cancer: Targets and Therapy 2015:DovepressDovepressmicroRNAs in breast cancerTable two (Continued)miRNA locus KRAS three UTR SNP rs61764370 T/G Comments let7 MRe Population Caucasian Clinical observation enhanced frequency in BRCA1 carriers/no danger association improved threat of TNBC Decreased risk improved danger and poor survival earlier age of onset enhanced threat enhanced threat Decreased risk Decreased general danger No risk association Decreased threat of eR+ BC No threat association increas.A/G rs12983273 T/C(Continued)Breast Cancer: Targets and Therapy 2015:submit your manuscript | www.dovepress.comDovepressGraveel et alDovepressTable 2 (Continued)Gene locus MIR423 SNP rs6505162 A/C Comments premiRNA Population Caucasian Jewish BRCA2 carriers Asians Caucasians African Americans european Americans African Americans european Americans African Americans european Americans Chinese Asians Caucasians Asians Caucasians Chinese Caucasians Asians Caucasians Asians Caucasians Asians Caucasians African Americans european Americans African Americans european Americans African Americans european Americans African Americans european Americans Asians Caucasians African Americans european Americans African Americans european Americans African Americans european Americans African Americans european Americans African Americans european Americans African Americans european Americans African Americans european Americans Jewish BRCA2 carriers Caucasian italian Chinese Jewish BRCA1 carriers Chinese Clinical observation Decreased threat Later age of onset No threat association No risk association No risk association Decreased threat of eR+ BC No threat association elevated general threat No risk association enhanced danger of eR- BC elevated danger elevated danger No risk association elevated danger No threat association elevated risk No danger association elevated danger No risk association enhanced risk No threat association Decreased threat No danger association elevated all round danger No danger association No danger association enhanced general danger No risk association Decreased risk of eR+ BC improved threat of eR- BC No risk association Decreased threat No risk association improved risk of eR+ No danger association No threat association Decreased danger of eR- BC Decreased danger of eR+ BC No risk association Decreased threat of eR+ No danger association No risk association improved all round risk Decreased all round risk No danger association No danger association enhanced threat of eR- BC increased danger elevated threat increased threat enhanced risk in eR+ earlier age of onset elevated risk (A allele) earlier age of onset (C allele) Decreased threat Decreased threat improved threat Lowered survival Reference 150 142 38 33 33 33 36 151 152 32 147 153 31 141 33 33 33 33 141 33 33 33 33 33 33 33 142 srep39151 43 154 155 156 jir.2014.0227 157 158 159MIR455 MIR487 MIR495 MIRrs2060133 C/G rs1951032 G/A rs2281611 C/A rs3746444 A/Grs3746444 T/CMIR513A-2 MIR544 MIR548A-2 MIR595 MIR605 MIR606 MIR608 MIRrs2018562 A/G rs10144193 A/T rs878175 A/G rs4909238 A/G rs2043556 *A rs12266981 G/A rs4919510 C/G rs8041885 A/G rs8041044 C/AMIR659 MIRrs5750504 T/A rs12586258 G/A rs7141987 A/GATF1 three UTR BMPR1B 3 UTR BRCA1 three UTR HPGD 3 UTR IGF-1R three UTR IL23R 3 UTRrs11169571 C/T rs1434536 C/T rs799917 C/T rs8752 G/A rs28674628 A/G rs10889677 A/CmiR320 MRe miR125b MRe miR638 MRe miR4855p MRe miR5155p MRe let7 MReIQGAP1 three UTR ITGB4 three UTRrs1042538 A/T rs743554 A/GmiR124 MRe miR34a MRepredictedChinese Swedish(Continued)submit your manuscript | www.dovepress.comBreast Cancer: Targets and Therapy 2015:DovepressDovepressmicroRNAs in breast cancerTable two (Continued)miRNA locus KRAS three UTR SNP rs61764370 T/G Comments let7 MRe Population Caucasian Clinical observation increased frequency in BRCA1 carriers/no danger association increased threat of TNBC Decreased threat improved risk and poor survival earlier age of onset enhanced danger enhanced risk Decreased threat Decreased all round danger No risk association Decreased threat of eR+ BC No risk association increas.
