Product Name :
G15
Description:
G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a Ki of 20 nM.
CAS:
1161002-05-6
Molecular Weight:
370.24
Formula:
C19H16BrNO2
Chemical Name:
(3aR,4R,9bS)-4-(6-bromo-2H-1,3-benzodioxol-5-yl)-3H,3aH,4H,5H,9bH-cyclopenta[c]quinoline
Smiles :
BrC1C=C2OCOC2=CC=1[C@@H]1NC2=CC=CC=C2[C@H]2C=CC[C@H]21
InChiKey:
YOLTZIVRJAPVPH-MJCKAROISA-N
InChi :
InChI=1S/C19H16BrNO2/c20-15-9-18-17(22-10-23-18)8-14(15)19-13-6-3-5-11(13)12-4-1-2-7-16(12)21-19/h1-5,7-9,11,13,19,21H,6,10H2/t11-,13-,19-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a Ki of 20 nM.|Product information|CAS Number: 1161002-05-6|Molecular Weight: 370.24|Formula: C19H16BrNO2|Chemical Name: (3aR,4R,9bS)-4-(6-bromo-2H-1,3-benzodioxol-5-yl)-3H,3aH,4H,5H,9bH-cyclopenta[c]quinoline|Smiles: BrC1C=C2OCOC2=CC=1[C@@H]1NC2=CC=CC=C2[C@H]2C=CC[C@H]21|InChiKey: YOLTZIVRJAPVPH-MJCKAROISA-N|InChi: InChI=1S/C19H16BrNO2/c20-15-9-18-17(22-10-23-18)8-14(15)19-13-6-3-5-11(13)12-4-1-2-7-16(12)21-19/h1-5,7-9,11,13,19,21H,6,10H2/t11-,13-,19-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 41.67 mg/mL (112.55 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Evofosfamide Autophagy |Shelf Life: ≥12 months if stored properly.Osemitamab In Vivo |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32379240 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|G15 (0.1-10 μM; 2 days) inhibits GPER-mediated proliferation stimulated by 17β-estradiol (E2) in A549 and H1793 cell lines. G15 (1 μM; 48 hours) inhibits the response of GPER stimulated by E2 and G1 in A549 and H1793 cell lines.|In Vivo:|G15 (1.46 mg/kg; i.h.; twice a week for 14 weeks) decreases the number of tumor nodules and tumor index increased by the E2 or G1 group in urethane-induced adenocarcinoma mice.|Products are for research use only. Not for human use.|
