Product Name :
CI-949
Description:
CI-949 is an allergic mediator release inhibitor, which inhibits histamine, leukotriene C4/D4 (LTC4/LTD4), and thromboxane B2 (TXB2) release with IC50s of 11.4 μM, 0.5 μM and 0.1 μM, respectively.
CAS:
104961-19-5
Molecular Weight:
392.41
Formula:
C20H20N6O3
Chemical Name:
5-methoxy-1-phenyl-3-(propan-2-yloxy)-N-(1H-1,2,3,4-tetrazol-5-yl)-1H-indole-2-carboxamide
Smiles :
COC1=CC2C(OC(C)C)=C(C(=O)NC3NN=NN=3)N(C=2C=C1)C1C=CC=CC=1
InChiKey:
JPTSIWRGXIZEOO-UHFFFAOYSA-N
InChi :
InChI=1S/C20H20N6O3/c1-12(2)29-18-15-11-14(28-3)9-10-16(15)26(13-7-5-4-6-8-13)17(18)19(27)21-20-22-24-25-23-20/h4-12H,1-3H3,(H2,21,22,23,24,25,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CI-949 is an allergic mediator release inhibitor, which inhibits histamine, leukotriene C4/D4 (LTC4/LTD4), and thromboxane B2 (TXB2) release with IC50s of 11.Anacardic Acid Technical Information 4 μM, 0.5 μM and 0.1 μM, respectively.|Product information|CAS Number: 104961-19-5|Molecular Weight: 392.Chamaejasmenin A Technical Information 41|Formula: C20H20N6O3|Chemical Name: 5-methoxy-1-phenyl-3-(propan-2-yloxy)-N-(1H-1,2,3,4-tetrazol-5-yl)-1H-indole-2-carboxamide|Smiles: COC1=CC2C(OC(C)C)=C(C(=O)NC3NN=NN=3)N(C=2C=C1)C1C=CC=CC=1|InChiKey: JPTSIWRGXIZEOO-UHFFFAOYSA-N|InChi: InChI=1S/C20H20N6O3/c1-12(2)29-18-15-11-14(28-3)9-10-16(15)26(13-7-5-4-6-8-13)17(18)19(27)21-20-22-24-25-23-20/h4-12H,1-3H3,(H2,21,22,23,24,25,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32491727 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CI-949 inhibits, in a dose-dependent manner, the release of histamine, leukotriene, and thromboxane from human basophilic leukocytes challenged with anti-IgE. The IC50 for inhibition of histamine release is 11.4 μM. Virtually complete inhibition of histamine release occurs at 100 μM, with negligible inhibition of release In Vivo:|Actively sensitized guinea-pigs are given i .p. doses of 30, 50, or 100 mg/kg of CI-949 between 20-120 min before aerosol challenge with antigen. A dose of 50 mg/kg i.p. of CI-949 protects conscious, aerosol-allergen challenged guinea-pigs for at least 1 h and 100 mg/kg i.p. or per os protects for at least 2 h. The animals are protected from collapse for at least I h after 50 and 100 mg/kg, and 100 mg/kg afforded complete protection up to 2h. An oral dose of 100 mg/kg at 2 h, but not at 4 h before challenge also inhibits collapse. A dose of 100 mg/kg at 4 h and again at 2 h before challenge is more effective than a single dose at 2 h.|Products are for research use only. Not for human use.|
