Name :
Recombinant Human IGF1R protein, DDK-tagged
Specification :
| Description : This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. | Source : Insect cells | Species : Human | Tag : DDK | Form : 50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol. | Molecular Mass : 22.2 kDa | Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining | Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions. | Concentration : >50 ug/mL as determined by microplate BCA method
Gene Information :
| Gene Name : IGF1R insulin-like growth factor 1 receptor [ Homo sapiens ] | Official Symbol : IGF1R | Synonyms : IGF1R; insulin-like growth factor 1 receptor; CD221; IGFIR; IGFR; JTK13; MGC18216; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor; MGC142170; MGC142172; | Gene ID : 3480 | mRNA Refseq : NM_000875 | Protein Refseq : NP_000866 | MIM : 147370 | UniProt ID : P08069 | Chromosome Location : 15q26.3 | Pathway : Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Apoptosis, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Focal Adhesion, organism-specific biosystem; | Function : ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; nucleotide binding; phosphatidylinositol 3-kinase binding; protein binding; protein tyrosine kinase activity; receptor activity;
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
Cadherin-11 ProteinGene ID
PTK7 ProteinGene ID
Popular categories:
Intercellular Adhesion Molecule 5 (ICAM-5)
CD138/Syndecan-1
