Recombinant Human IL13RA1 Protein, C-His-tagged

Specification :
| Description : The Th2 cytokine Interleukin-13 (IL-13) plays a critical role in allergen-induced airway hyper-responsiveness (AHR). Two different receptors exist for IL-13, designated IL-13Ra1 and 2. IL-13Ra1 exists as a heterodimer of IL-13Ra1 and IL-4Ra as a signaling subunit, whereas IL-13Ra2 acts as a decoy receptor for IL-13. Furthermore, TNFa or IL-4 stimulation induces IL-13Ra2 upregulation, while IL-13Ra1 is constitutively expressed. Cell surface localization of IL-13Ra2 abrogates IL-13 signaling, thus IL-13 induced translocation of the receptor from the cytoplasm provides a mechanism for negative-feedback of IL-13 signaling. IL-13Ra1 expression is predominant in B cells, monocytes and T cells, whereas IL-13Ra2 expression is highest in glioma cells. | Source : E. coli | Species : Human | Tag : C-His | Molecular Mass : ~35 kDa | AA Sequence : GGGGAAPTETQPPVTNLSVSVENLC TVIWTWNPPEGASSNCSLWYFSHFG DKQDKKIAPETRRSIEVPLNERICL QVGSQCSTNESEKPSILVEKCISPP EGDPESAVTELQCIWHNLSYMKCSW LPGRNTSPDTNYTLYYWHRSLEKIH QCENIFREGQYFGCSFDLTKVKDSS FEQHSVQIMVKDNAGKIKPSFNIVP LTSRVKPDPPHIKNLSFHNDDLYVQ WENPQNFISRCLFYEVEVNNSQTET HNVFYVQEAKCENPEFERNVENTSC FMVPGVLPDTLNTVRIRVKTNKLCY EDDKLWSNWSQEMSIGKKRNST | Purity : Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). | Notes : For research use only, not for use in diagnostic procedure. | Storage : Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. | Concentration : ≥0.5 mg/mL | Storage Buffer : PBS, 4M Urea, pH7.4