Recombinant Human IL17RA Protein, Fc-tagged

Specification :
| Description : Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. | Source : HEK293 | Species : Human | Tag : Fc | Form : Lyophilized | Molecular Mass : 60.1 kDa | Protein Length : 866 | AA Sequence : MGAARSPPSAVPGPLLGLLLLLLGV LAPGGASLRLLDHRALVCSQPGLNC TVKNSTCLDDSWIHPRNLTPSSPKD LQIQLHFAHTQQGDLFPVAHIEWTL QTDASILYLEGAELSVLQLNTNERL CVRFEFLSKLRHHHRRWRFTFSHFV VDPDQEYEVTVHHLPKPIPDGDPNH QSKNFLVPDCEHARMKVTTPCMSSG SLWDPNITVETLEAHQLRVSFTLWN ESTHYQILLTSFPHMENHSCFEHMH HIPAPRPEEFHQRSNVTLTLRNLKG CCRHQVQIQPFFSSCLNDCLRHSAT VSCPEMPDTPEPIPDYMPLWVYWFI TGISILLVGSVILLIVCMTWRLAGP GSEKYSDDTKYTDGLPAADLIPPPL KPRKVWIIYSADHPLYVDVVLKFAQ FLLTACGTEVALDLLEEQAISEAGV MTWVGRQKQEMVESNSKIIVLCSRG TRAKWQALLGRGAPVRLRCDHGKPV GDLFTAAMNMILPDFKRPACFGTYV VCYFSEVSCDGDVPDLFGAAPRYPL MDRFEEVYFRIQDLEMFQPGRMHRV GELSGDNYLRSPGGRQLRAALDRFR DWQVRCPDWFECENLYSADDQDAPS LDEEVFEEPLLPPGTGIVKRAPLVR EPGSQACLAIDPLVGEEGGAAVAKL EPHLQPRGQPAPQPLHTLVLAAEEG ALVAAVEPGPLADGAAVRLALAGEG EACPLLGSPGAGRNSVLFLPVDPED SPLGSSTPMASPDLLPEDVREHLEG LMLSLFEQSLSCQAQGGCSRPAMVL TDPHTPYEEEQRQSVQSDQGYISRS SPQPPEGLTEMEEEEEEEQDPGKPA LPLSPEDLESLRSLQRQLLFRQLQK NSGWDTMGSESEGPSA | Purity : > 98% | Applications : WB; ELISA; FACS; FC | Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. | Storage : At -20 centigrade. | Concentration : 1 mg/mL | Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution. | Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.