Recombinant Human IL17RA protein, His-tagged

Specification :
| Description : Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. | Source : E. coli | Species : Human | Tag : His | Form : Freeze-dried powder | Molecular Mass : 22kDa as determined by SDS-PAGE reducing conditions. | Protein length : Pro377~Phe534 (Accession # Q96F46) | Endotoxin : | Purity : >95% | Characteristic : The isoelectric point is 6.4. | Applications : SDS-PAGE; WB; ELISA; IP. | Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. | Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. | Storage buffer : Supplied as lyophilized form in PBS, pH 7.4, containing 5% sucrose, 0.01% sarcosyl. | Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.