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Name :
Recombinant Human IL3RA, Fc-tagged

Specification :
| Description : The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. | Conjugation : Fc | Form : Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not rec | Purity : >95% by SDS-PAGE | Storage buffer : Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin | Storage : Store at +4°C. | Sequences of amino acids : TKEDPNPPITNLRMKAKAQQLTWDL NRNVTDIECVKDADY SMPAVNNSYCQFGAISLCEVTNYTV RVANPPFSTWILF PENSGKPWAGAENLTCWIHDVDFLS CSWAVGPGAPADV QYDLYLNVANRRQQYECLHYKTDAQ GTRIGCRFDDISR LSSGSQSSHILVRGRSAAFGIPCTD KFVVFSQIEILTP PNMTAKCNKTHSFMHWKMRSHFNRK FRYELQIQKRMQPVITEQVRDRTSF QLLNPGTYTVQIRARERVYEFLSAW STP QRFECDQEEGANTRGGRVDGIQWIP KVDKKVEPKSCDK THTCPPCPAPELLGGPSVFLFPPKP KDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVH NAKTKPREEQYNS TYRVVSVLTVLHQDWLNGKEYKCRV SNKALPAPIEKTI SKAKGQPREPQVYTLPPSRDELTKN QVSLTCLVKGFYPSDIAVEWESNGQ PENNYKTTPPVLDSDGSFFLYSKLT VDK SRWQQGNVFSCSVMHEALHNHYTQK SLSLSPGK | Sequence Similarities : Belongs to the type I cytokine receptor family. Type 5 subfamily.

Gene Information :
| Gene Name : IL3RA interleukin 3 receptor, alpha (low affinity) [ Homo sapiens ] | Official Symbol : IL3RA | Synonyms : IL3RA; interleukin 3 receptor, alpha (low affinity); interleukin-3 receptor subunit alpha; CD123; | Gene ID : 3563 | mRNA Refseq : NM_002183 | Protein Refseq : NP_002174 | MIM : 308385 | Uniprot ID : P26951 | Chromosome Location : Xp22.3 and Yp13.3 | Pathway : Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; | Function : interleukin-3 receptor activity; receptor activity;

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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Author: Cholesterol Absorption Inhibitors