Recombinant Human IL4R Protein

Specification :
| Description : This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq | Source : Wheat Germ | Species : Human | Form : Liquid | Molecular Mass : 25.6 kDa | AA Sequence : MGWLCSGLLFPVSCLVLLQVASSGN MKVLQEPTCVSDYMSISTCEWKMNG PTNCSTELRLLYQLVFLLSEAHTCI PENNGGAGCVCHLLMDDVVSADNYT LDLWAGQQLLWKGSFKPSEHVKPRA PGNLTVHTNVSDTLLLTWSNPYPPD NYLYNHLTYAVNIWSENDPADFRIY NVTYLEPSLRIAASTLKSGISYRAR VRAWAQCYNTTWSEWSPSTKWHNSN IC | Applications : Antibody ProductionFunctional StudyCompound Screening | Usage : Heating may cause protein aggregation. Please do not heat this product before electrophoresis. | Notes : Best use within three months from the date of receipt of this protein. | Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. | Storage Buffer : 25 mM Tris-HCl of pH8.0 containing 2% glycerol.