Recombinant Human IL7R Protein, C-His-tagged

Specification :
| Description : Interleukin 7 (IL-7) was originally described as a factor capable of inducing in vitro proliferation of pre-B cells from marrow cultures. The IL-7 gene encodes a protein 177 amino acids in length. IL-7 exerts its biological function through the IL-7 receptor which is expressed on pre-B cells, thymocytes and bone marrow-derived macrophages. The IL-7 receptor is composed of an IL-7 receptor-specific chain and the IL-2 receptor γ chain common to the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors. IL-7 stimulation leads to the activation of Janus tyrosine kinase family members JAK1 and JAK3. Other studies have shown that in T cells, the IL-7 receptor-specific chain associates with the Src kinases family Lck and Fyn. IL-7 induces phosphorylation of insulin receptor substrate-1 (IRS-1) and Insulin receptor substrate-2 (IRS-2), originally called 4PS. | Source : E. coli | Species : Human | Tag : C-His | Molecular Mass : ~24 kDa | AA Sequence : ESGYAQNGDLEDAELDDYSFSCYSQ LEVNGSQHSLTCAFEDPDVNITNLE FEICGALVEVKCLNFRKLQEIYFIE TKKFLLIGKSNICVKVGEKSLTCKK IDLTTIVKPEAPFDLSVVYREGAND FVVTFNTSHLQKKYVKVLMHDVAYR QEKDENKWTHVNLSSTKLTLLQRKL QPAAMYEIKVRSIPDHYFKGFWSEW SPSYYFRTPEINNSSGEMD | Purity : Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). | Notes : For research use only, not for use in diagnostic procedure. | Storage : Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. | Concentration : ≥0.5 mg/mL | Storage Buffer : PBS, 4M Urea, pH7.4