Recombinant Human IL18RAP Protein, His-tagged

Specification :
| Description : Interleukin-18 (IL-18) has been identified as a molecule that induces IFN-γ production and enhances NK cell cytotoxicity. IL-18 receptor (IL-18R) is a type I membrane protein present in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta and heart, and absent from brain, skeletal muscle, pancreas and kidney. IL-18R is present in Hodgkin’s disease cell lines, and does not bind IL-1α or IL-1β. The association of IL-18 to IL-18R leads to activation of NFκB. At present two subunits of IL-18R have been characterized: IL-18Rα and IL-18Rβ. IL-18Rα has been described as the ligand-binding chain and IL-18Rβ as the signal-transduction chain. | Source : E. coli | Species : Human | Tag : His | Molecular Mass : ~43 kDa | AA Sequence : MFNISGCSTKKLLWTYSTRSEEEFV LFCDLPEPQKSHFCHRNRLSPKQVP EHLPFMGSNDLSDVQWYQQPSNGDP LEDIRKSYPHIIQDKCTLHFLTPGV NNSGSYICRPKMIKSPYDVACCVKM ILEVKPQTNASCEYSASHKQDLLLG STGSISCPSLSCQSDAQSPAVTWYK NGKLLSVERSNRIVVDEVYDYHQGT YVCDYTQSDTVSSWTVRAVVQVRTI VGDTKLKPDILDPVEDTLEVELGKP LTISCKARFGFERVFNPVIKWYIKD SDLEWEVSVPEAKSIKSTLKDEIIE RNIILEKVTQRDLRRKFVCFVQNSI GNTTQSVQLKEKR | Purity : Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). | Notes : For research use only, not for use in diagnostic procedure. | Storage : Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. | Storage Buffer : PBS, 4M Urea, pH7.4