Name :
Recombinant Human IL2RB, Fc-tagged
Specification :
| Description : The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. | Conjugation : Fc | Biological activity : IL2RB-29776TH bound to protein A sepharose beads is able to pull down its ligand, IL2. | Form : Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not reco | Purity : >95% by SDS-PAGE | Storage buffer : Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin | Storage : Store at +4°C. | Sequences of amino acids : Theoretical Sequence:AVNGTSQFTCFYNSRANISCVWSQD GALQ DTSCQVHAWPDRRRWNQTCELLPVS QASWACNLILGAP DSQKLTTVDIVTLRVLCREGVRWRV MAIQDFKPFENLR LMAPISLQVVHVETHRCNISWEISQ ASHYFERHLEFEARTLSPGHTWEEA PLLTLKQKQEWICLETLTPDTQYEF QVR VKPLQGEFTTWSPWSQPLAFRTKPA ALGIPKVDKKVEP KSCDKTHTCPPCPAPELLGGPSVFL FPPKPKDTLMISR TPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPRE EQYNSTYRVVSVLTVLHQDWLNGKE YKCKVSNKALPAPIE KTISKAKGQPREPQVYTLPPSRDEL TKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPP VLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPGK
Gene Information :
| Gene Name : IL2RB interleukin 2 receptor, beta [ Homo sapiens ] | Official Symbol : IL2RB | Synonyms : IL2RB; interleukin 2 receptor, beta; IL15RB, interleukin 15 receptor, beta; interleukin-2 receptor subunit beta; CD122; | Gene ID : 3560 | mRNA Refseq : NM_000878 | Protein Refseq : NP_000869 | MIM : 146710 | Uniprot ID : P14784 | Chromosome Location : 22q13 | Pathway : Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; Endocytosis, organism-specific biosystem; | Function : interleukin-2 binding; interleukin-2 receptor activity; contributes_to interleukin-2 receptor activity; receptor activity;
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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