Recombinant Human IL6R Protein

Specification :
| Description : Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. The protein encoded by this gene is a subunit of the receptor complex for IL6. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq | Source : Wheat Germ | Species : Human | Form : Liquid | Molecular Mass : 51.5 kDa | AA Sequence : MLAVGCALLAALLAAPGAALAPRRC PAQEVARGVLTSLPGDSVTLTCPGV EPEDNATVHWVLRKPAAGSHPSRWA GMGRRLLLRSVQLHDSGNYSCYRAG RPAGTVHLLVDVPPEEPQLSCFRKS PLSNVVCEWGPRSTPSLTTKAVLLV RKFQNSPAEDFQEPCQYSQESQKFS CQLAVPEGDSSFYIVSMCVASSVGS KFSKTQTFQGCGILQPDPPANITVT AVARNPRWLSVTWQDPHSWNSSFYR LRFELRYRAERSKTFTTWMVKDLQH HCVIHDAWSGLRHVVQLRAQEEFGQ GEWSEWSPEAMGTPWTESRSPPAEN EVSTPMQALTTNKDDDNILFRDSAN ATSLPVQDSSSVPLPTFLVAGGSLA FGTLLCIAIVLRFKKTWKLRALKEG KTSMHPPYSLGQLVPERPRPTPVLV PLISPPVSPSSLGSDNTSSHNRPDA RDPRSPYDISNTDYFFPR | Applications : Antibody ProductionFunctional StudyCompound Screening | Usage : Heating may cause protein aggregation. Please do not heat this product before electrophoresis. | Notes : Best use within three months from the date of receipt of this protein. | Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. | Storage Buffer : 25 mM Tris-HCl of pH8.0 containing 2% glycerol.