In Lg-Flo1p Domain Uniprot [Number of Repeats] Flocculation protein Lg-Flo1pFlocculin [Number 1 of Repeats]Flocculin_t3 8 3 [Number of Repeats] 8 3Organism NCBI Taxonomy ID Saccharomyces pastorianusA0A0L8VPM7_9SACH YHR213Wp https: flocculin-like //www.uniprot.org/uniprot/A0A0L8VPM7 protein A0A0L8VPM7_9SACH 2021) YHR213Wp flocculin-like (accessed on 24 OctoberS. cerevisiae var. boulardiiA0A0L8VPM7_9SACHprotein YHR213Wp flocculin-like protein1 1 1 1 11 1 five 5 00 0 0 0 1GLEYA GLEYA GLEYAQ6FR82_CANGA PA14 domainQ6FR82_CANGA PA14 domain-containing protein, Epa23p https://www.uniprot.org/uniprot/Q6FR82 containing 1 Q6FR82_CANGA PA14 domain-containing protein, Epa23p (accessed on 24 October 2021) protein, Epa23pPathogens 2021, 10, xxFOR PEER Assessment Pathogens 2021, 10, FOR PEER REVIEWC4Y9G0_CLAL4 C4Y9G0_CLAL4 C4Y9G0_CLALPA14 domain-containing protein PA14 domain-containing protein PA14 domaincontaining proteinhttps://www.uniprot.org/uniprot/C4Y9G0 (accessed on 24 October 2021)306902 https://www.uniprot.org/taxonomy/306902 306902 306902 (accessed on 24 October 2021)Pathogens 2021, 10,14 ofEpa adhesins mediate adherence to human epithelial and endothelial cells by recognizing glycans containing terminal galactose residues [47] and show the highest affinity for the Thomsen-Friedenreich (T or TF) antigen (Gal-1,3-GalNAc), which likely mediates N-Epap adherence to hugely glycosylated proteins like mucins [95]. It was also demonstrated that N-Epa1p binds to fibronectin from human plasma [53,160] at the same time as to mucin [53]. Lots of other human receptors of Epa adhesins happen to be predicted by constructing their lectin-glycan interaction (LGI) network, which is an strategy that is certainly according to linking glycan array screening final results with the adhesins to a human glycoprotein database [53]. The Epa1p, Epa6p and Epa7p LGI network Bafilomycin C1 Fungal revealed that a sizable set of receptors are present in body fluids or displayed on human cells in numerous body systems; receptors incorporated quite a few mucins (urogetinal, respiratory, exocrine and digestive system), -casein (exocrine program), epidermal growth element receptor (EGFR, WZ8040 supplier urogenital system), cadherin-5 (CD144, urogenital method), lactotransferrin (LTF, exocrine program), serotransferrin (TF, hemic method), immunoglobulin M (IgM, hemic method), tumor necrosis aspect alpha (TNF, hemic program), P-selectin glycoprotein ligand (PSGL-1, hemic program), leukosialin (CD43, respiratory system), receptor-type tyrosine-protein phosphatase C (CD45, hemic program), von Willebrand issue (vWF, hemic system), -secretase 1 (BACE1, urogenital technique), lysosome-associated membrane glycoprotein 1 (LAMP1/2, hemic system), plasminogen two (PLG, urogenital program). four.1.two. Candida lusitaniae (Clavispora lusitaniae) Clavispora lusitaniae, which is the teleomorph of C. lusitaniae, is definitely an environmental saprophytic yeast that belongs to the CTG clade of Candida [161] (Table two). C. lusitaniae can behave rarely as an opportunistic pathogen in humans, and its most typical threat elements contain immunocompromised patients generally with an underlying malignancy [162]. On the other hand, nosocomial acquisition secondary to an indwelling urinary catheter [163], and catheterassociated C. lusitaniae candidemia [164] have also been reported. Amphotericin B resistance amongst isolates of C. lusitaniae has distinguished it amongst Candida species [165]. The adhesion of C. lusitaniae to abiotic surfaces (polystyrene and steel surfaces) has been demonstrated [166]. C. lusitaniae strains can express ad.
