Nts with SLE and 25 standard controlsTesticular damage immunosuppressive agents Silva et al. (15) 2002 four individuals with juvenile SLE 1 patient with azoospermia and elevated FSH / 1 patient with serious oligospermia. Both treated with CYC Alkylating agents may possibly induce testicular damagePresence of anti-sperm antibody D’Cruz et al. (16) 1994 33 sufferers with SLE, 33 patients with ASA and 20 typical controls 32 individuals with RA, 14 with BD, eight with SLE and 80 healthier controls 42 sufferers with SLE had ASA ASA has high frequency in SLE patients SLE could induce ASA in patients and influence fertilityShiraishi et al. (17)13 SLE individuals had ASAPresence of sex chromosomes aneuploid Dillon et al. (18) 2012 316 sufferers with SLE eight individuals with sex chromosomes alterations Sex chromosomes aneuploid is far more frequent in SLE guys and may perhaps effect their fertilityNote: slE = systemic lupus erythematosus; lH = luteinizing hormone; FsH = follicle-stimulating hormone; CyC = cyclophosphamide; Ra = rheumathoid arthritis; asa = antisperm antibody, bD = Beh t illness.et al. (19) evaluated five sufferers with juvenile DM and compared with 10 age-matched healthier controls regarding testicular volume, sperm evaluation, ASA and sex hormone profile. One patient had made use of CYC using a cumulative dose of six.6g and seasoned transient azoospermia with normaliza-tion following 5 years of medication withdrawal. All DM sufferers had teratospermia, one had ASA and none had abnormal hormone profile. A later study investigated ten adult patients and ten age-matched healthy controls. DM subjects had lower sperm concentration, reduce total motileibju | Male fertility in rheuMatic diseasesTable 2 Dermatomyositis and male fertility.Author Year Study Population 5 post-pubertal males with DM and five healthier controls Outcomes one hundred teratozoospermia / Azoospermia in the course of CYC remedy Low concentration, low sperm abnormalities, low motile count, reduced testicular volumes in DM patients ConclusionMoraes et al.MIG/CXCL9 Protein site (19)No considerable difference among sufferers and regular controls concerning hormonal levels or sperm analysis DM may possibly have an effect on testicular function and sex hormones levels / Disease activity and CYC could induce gonadal dysfunctionMoraes et al.TGF beta 2/TGFB2 Protein Biological Activity (20)10 post-pubertal males with DM and ten healthy controlsNote: DM = dermatomyositis; CyC = cyclophosphamide.PMID:23910527 sperm count and lower standard sperm morphology percentage. Illness activity seemed to become a relevant issue in 4 individuals and CYC in a single of them (20). Rheumatoid arthritis Two publications assessed fertility on RA sufferers (Table-3). Gordon et al. (21) evaluated 31 patients with RA, 33 with AS and 95 healthful controls. Sufferers with RA had reduced serum testosterone levels and greater FSH and LH levels than controls. Ten individuals (33 ) admitted periods of erectile dysfunction while 15 (50 ) also referred decreased libido when suffering from arthritis. Four sufferers referred difficulty to conceive, amongst them, two did not seek healthcare assistance for infertility. Nineteen males had effectively fathered children and also the other folks have been nevertheless singles.In 2008, Shiraishi et al. (17) evaluated 32 RA individuals and located one with serum ASA. The patient was 74 years old as well as the disease onset was at the age of 60 years. He had currently two children before getting diagnosed with all the disease so the relation involving fertility status as well as the presence with the antibody couldn’t be addressed nor its relation using the disease. Ankylosing spondylitis 4 publications have been chosen regarding the A.
