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The estimated number of Americans that endure from spinal cord injury (SCI) is 270,000 persons, with 12,000 new cases reported annually (National Spinal Cord Statistical Center, 2012).PMID:23381626 The principle problem with SCI is that a cascade of independent events are initiated after the trauma; therefore, a combination therapy is required to greater strategy the progressive stages of this illness (Oudega et al., 2012). The devastating effects of SCI are connected with its instant and secondary effects that result in cell degeneration in the trauma site and surrounding places. Immediate harm that outcomes in the direct physical impact includes hemorrhagic necrosis, excitotoxicity and the production of free of charge radicals by the injured tissue (Bramlett and Dietrich, 2007). The secondary harm can be a consequence mostly of an inflammatory response which includes apoptotic cell death, cyst formation and improvement of scar tissue (Hulsebosch CE, 2002). As a result, a therapeutic approach that addresses each stages is crucial to target the situation and strengthen the outcome of SCI sufferers. One of several clinical approaches to cut down neural damage right after SCI would be to curtail the inflammatory response by applying.
