The big metabolite of arecoline, arecoline N-oxide, is described to be reasonably mutagenic to Salmonella typhimurium tester strains TA a hundred and TA ninety eight. But this mutagenicity was potently inhibited by glutathione, N-acetylcysteine, and cysteine [ninety three]
In actuality, GSH depletion and reduction of glutathione S-transferase (GST) activity have been shown...